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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AAK1 All Species: 10.3
Human Site: S523 Identified Species: 32.38
UniProt: Q2M2I8 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q2M2I8 NP_055726.3 863 93578 S523 P V V S Q G G S Q Q Q L M Q N
Chimpanzee Pan troglodytes XP_001138187 865 93810 S524 P V V S Q G G S Q Q Q L M Q N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_531855 473 51892 I173 H Q C K T P I I H R D L K V E
Cat Felis silvestris
Mouse Mus musculus Q3UHJ0 959 103328 A532 P V G S Q G G A Q Q Q L M Q N
Rat Rattus norvegicus P0C1X8 962 103742 S536 P V V S Q G G S Q Q Q L M Q N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417663 953 102927 P518 P V M Q Q G A P A Q Q Q L M Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_625109 598 65629 K298 I A F Q I L G K E C P V Q N L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40494 810 91014 S494 I T S K S L S S T K E I A A P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 N.A. 53.7 N.A. 80.7 79.9 N.A. N.A. 71.4 N.A. N.A. N.A. N.A. 36.7 N.A. N.A.
Protein Similarity: 100 99.6 N.A. 54.4 N.A. 83.1 82.7 N.A. N.A. 77.9 N.A. N.A. N.A. N.A. 50 N.A. N.A.
P-Site Identity: 100 100 N.A. 6.6 N.A. 86.6 100 N.A. N.A. 40 N.A. N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 100 100 N.A. 13.3 N.A. 93.3 100 N.A. N.A. 53.3 N.A. N.A. N.A. N.A. 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 38.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 0 0 0 0 13 13 13 0 0 0 13 13 0 % A
% Cys: 0 0 13 0 0 0 0 0 0 13 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 13 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 13 0 13 0 0 0 13 % E
% Phe: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 13 0 0 63 63 0 0 0 0 0 0 0 0 % G
% His: 13 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % H
% Ile: 25 0 0 0 13 0 13 13 0 0 0 13 0 0 0 % I
% Lys: 0 0 0 25 0 0 0 13 0 13 0 0 13 0 0 % K
% Leu: 0 0 0 0 0 25 0 0 0 0 0 63 13 0 13 % L
% Met: 0 0 13 0 0 0 0 0 0 0 0 0 50 13 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 50 % N
% Pro: 63 0 0 0 0 13 0 13 0 0 13 0 0 0 13 % P
% Gln: 0 13 0 25 63 0 0 0 50 63 63 13 13 50 13 % Q
% Arg: 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % R
% Ser: 0 0 13 50 13 0 13 50 0 0 0 0 0 0 0 % S
% Thr: 0 13 0 0 13 0 0 0 13 0 0 0 0 0 0 % T
% Val: 0 63 38 0 0 0 0 0 0 0 0 13 0 13 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _